The formation of N-alkylprotoporphyrin IX and destruction of cytochrome P-450 in the liver of rats after treatment with 3,5-diethoxycarbonyl-1,4-dihydrocollidine and its 4-ethyl analog.

Suppr

超能文献

作者信息

Coffman B L, Ingall G, Tephly T R

出版信息

Arch Biochem Biophys. 1982 Oct 1;218(1):220-4. doi: 10.1016/0003-9861(82)90339-3.

DOI:10.1016/0003-9861(82)90339-3

PMID:7149729

Abstract

摘要

相似文献

The formation of N-alkylprotoporphyrin IX and destruction of cytochrome P-450 in the liver of rats after treatment with 3,5-diethoxycarbonyl-1,4-dihydrocollidine and its 4-ethyl analog.

Arch Biochem Biophys. 1982 Oct 1;218(1):220-4. doi: 10.1016/0003-9861(82)90339-3.

Ferrochelatase-inhibitory activity and N-alkylprotoporphyrin formation with analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) containing extended 4-alkyl groups: implications for the active site of ferrochelatase.含延长4-烷基的3,5-二乙氧羰基-1,4-二氢-2,4,6-三甲基吡啶（DDC）类似物的亚铁螯合酶抑制活性及N-烷基原卟啉的形成：对亚铁螯合酶活性位点的意义

Mol Pharmacol. 1986 Oct;30(4):352-7.

Isolation of an N-alkylprotoporphyrin IX from chick embryo livers following the administration of 3,5-diethoxycarbonyl-1,4-dihydro-4-ethyl-2,6-dimethylpyridine.

Can J Physiol Pharmacol. 1987 Jul;65(7):1500-2. doi: 10.1139/y87-235.

N-Alkylprotoporphyrin IX formation in 3,5-dicarbethoxy-1,4-dihydrocollidine-treated rats. Transfer of the alkyl group from the substrate to the porphyrin.3,5-二乙氧羰基-1,4-二氢可力丁处理的大鼠体内N-烷基原卟啉IX的形成。烷基从底物向卟啉的转移。

J Biol Chem. 1981 Jul 10;256(13):6708-13.

Suicidal destruction of cytochrome P-450 and reduction of ferrochelatase activity by 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine and its analogues in chick embryo liver cells.3,5 - 二乙氧基羰基 - 1,4 - 二氢 - 2,4,6 - 三甲基吡啶及其类似物对鸡胚肝细胞中细胞色素P - 450的自杀性破坏及亚铁螯合酶活性的降低

Mol Pharmacol. 1985 Apr;27(4):459-65.

Studies on the mechanism of experimental porphyria and ferrochelatase inhibition produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine.3,5 - 二乙氧羰基 - 1,4 - 二氢可力丁所致实验性卟啉症及铁螯合酶抑制机制的研究

Int J Biochem. 1980;12(5-6):993-8. doi: 10.1016/0020-711x(80)90200-1.

Inactivation of cytochrome P450 and inhibition of ferrochelatase by analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine with 4-nonyl and 4-dodecyl substituents.

Can J Physiol Pharmacol. 1992 Aug;70(8):1069-74. doi: 10.1139/y92-148.

N-alkylation of the haem moiety of cytochrome P-450 caused by substituted dihydropyridines. Preferential attack of different pyrrole nitrogen atoms after induction of various cytochrome P-450 isoenzymes.取代二氢吡啶引起的细胞色素P-450血红素部分的N-烷基化。诱导各种细胞色素P-450同工酶后不同吡咯氮原子的优先攻击。

Biochem J. 1983 May 1;211(2):455-61. doi: 10.1042/bj2110455.

Stimulation of the pathway of porphyrin synthesis in the liver of rats and mice by griseofulvin, 3,5-Diethoxycarbonyl-1,4-dihydrocollidine and related drugs: evidence for two basically different mechanisms.灰黄霉素、3,5-二乙氧羰基-1,4-二氢可力丁及相关药物对大鼠和小鼠肝脏卟啉合成途径的刺激作用：两种根本不同机制的证据

Biochem J. 1975 Jan;146(1):285-7. doi: 10.1042/bj1460285.

Formation of N-alkylprotoporphyrin IX after interaction of porphyrinogenic xenobiotics with rat liver microsomes.

J Pharmacol Toxicol Methods. 1999 Nov;42(3):107-13. doi: 10.1016/s1056-8719(99)00050-7.

引用本文的文献

-Methyl Protoporphyrin IX: An Understudied Porphyrin.- 原卟啉 IX 甲酯：一种研究不足的卟啉。

Chem Res Toxicol. 2022 Dec 19;35(12):2186-2193. doi: 10.1021/acs.chemrestox.2c00214. Epub 2022 Dec 2.

Formation of N-methyl protoporphyrin in chemically-induced protoporphyria. Studies with a novel porphyrogenic agent.

Arch Toxicol. 1993;67(3):179-85. doi: 10.1007/BF01973305.

Formation of N-alkylated protoporphyrin IX in the livers of mice after diethylnitrosamine treatment.二乙基亚硝胺处理后小鼠肝脏中N-烷基化原卟啉IX的形成。

Biochem J. 1983 Jun 15;212(3):599-608. doi: 10.1042/bj2120599.

Biochem J. 1983 May 1;211(2):455-61. doi: 10.1042/bj2110455.

Quantitative analysis of flux along the gluconeogenic, glycolytic and pentose phosphate pathways under reducing conditions in hepatocytes isolated from fed rats.对从喂食大鼠分离出的肝细胞在还原条件下沿糖异生、糖酵解和磷酸戊糖途径的通量进行定量分析。

Biochem J. 1983 Jun 15;212(3):585-98. doi: 10.1042/bj2120585.

Ferrochelatase and N-alkylated porphyrins.亚铁螯合酶与N-烷基化卟啉

Mol Cell Biochem. 1984 Sep;64(2):127-37. doi: 10.1007/BF00224769.

Factors responsible for the formation of different N-alkylated porphyrins in rat liver microsomal systems exposed to norethindrone. The role of 3 alpha-hydroxysteroid dehydrogenase.负责在暴露于炔诺酮的大鼠肝脏微粒体系统中形成不同N-烷基化卟啉的因素。3α-羟基类固醇脱氢酶的作用。

Biochem J. 1986 Jun 1;236(2):379-87. doi: 10.1042/bj2360379.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验