Lack of behavioural effects following intraventricular infusion of somatostatin in the conscious goat.

The effect of IV or intracerebroventricular (ICV) administration of somatostatin was studied on the behaviour of conscious goats. The doses of somatostatin infused IV were 100 and 300 microgram for 30 min and 600 microgram for 6 min. The doses infused ICV were 10 and 100 microgram for 30 min and 600 microgram for 6 min. In contrast to earlier reports on experiments with rats ,no behavioral effects whatsoever were seen in goat. IV infusion of 100 to 600 microgram and ICV infusion of 600 microgram of somatostatin caused a difinite reduction in the secretion of insulin and growth hormone, but had no effect on the concentration of blood glucose. The reason why neither IV nor ICV administration of somatostatin had any behavioural effects in the conscious goat, in contrast to the effects in rat, cannot be explained with certainty. This may be due to species specificity, to the amount of somatostatin reaching the central nervous system, or to some metabolic changes in rat but not in goat.