Lowe N J, Chalet M, Breeding J, Kean C, Russell D H
Arch Dermatol. 1982 Dec;118(12):993-6.
We have previously described the clinical and dermatopathologic features of a psoriasiform dermatosis in a rhesus monkey (Macaca mulatta). This animal has been studied further in attempts to characterize its skin disease. Epidermal cell DNA synthesis was measured following the intradermal injection of tritiated thymidine. Epidermal cell labeling indexes in the involved and uninvolved skin of the affected monkey and in the skin of a normal monkey were compared. The labeling indexes in the involved skin were significantly increased as compared with uninvolved skin; they were also significantly higher than in normal skin. Epidermal polyamine assays showed increased epidermal putrescine in involved skin together with increased spermidine and an increased spermidine-spermine ratio compared with uninvolved and normal skin sites.
我们之前已经描述过一只恒河猴（猕猴）患有的银屑病样皮肤病的临床和皮肤病理学特征。为了进一步明确其皮肤疾病的特征，对这只动物进行了深入研究。在皮内注射氚标记胸腺嘧啶核苷后，测量表皮细胞DNA合成。比较了患病猴子受累皮肤和未受累皮肤以及正常猴子皮肤的表皮细胞标记指数。与未受累皮肤相比，受累皮肤的标记指数显著增加；也明显高于正常皮肤。表皮多胺检测显示，与未受累和正常皮肤部位相比，受累皮肤中的表皮腐胺增加，同时亚精胺增加，亚精胺与精胺的比值也增加。
