胰高血糖素对瓜氨酸生物合成的急性影响。
Acute effects of glucagon on citrulline biosynthesis.
作者信息
Rabier D, Briand P, Petit F, Parvy P, Kamoun P, Cathelineau L
出版信息
Biochem J. 1982 Sep 15;206(3):627-31. doi: 10.1042/bj2060627.
Abstract
Mitochondria isolated from livers of rats fed on different diets showed altered capacity to synthesize citrulline. Glucagon, 15 min after injection, increases citrulline biosynthesis, except after the high-protein diet. A significant correlation between citrulline biosynthesis and N-acetylglutamate content with and without glucagon treatment was shown when rats were fed on a standard or a carbohydrate diet. Different diets modified carbamoyl phosphate synthetase I (EC 6.3.4.16) and N-acetylglutamate synthase (acetyl-CoA:L-glutamate N-acetyltransferase, EC 2.3.1.1) activities. Glucagon did not modify these activities.
摘要
从喂食不同饮食的大鼠肝脏中分离出的线粒体显示出合成瓜氨酸的能力发生了改变。注射15分钟后，除了高蛋白饮食组外，胰高血糖素可增加瓜氨酸的生物合成。当大鼠喂食标准饮食或碳水化合物饮食时，无论有无胰高血糖素处理，瓜氨酸生物合成与N - 乙酰谷氨酸含量之间均显示出显著相关性。不同饮食改变了氨甲酰磷酸合成酶I（EC 6.3.4.16）和N - 乙酰谷氨酸合成酶（乙酰辅酶A：L - 谷氨酸N - 乙酰转移酶，EC 2.3.1.1）的活性。胰高血糖素未改变这些活性。
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