亚微摩尔浓度的线粒体外Ca2+可刺激大鼠肝脏线粒体的瓜氨酸合成速率。
Sub-micromolar concentrations of extramitochondrial Ca2+ stimulate the rate of citrulline synthesis by rat liver mitochondria.
作者信息
Johnston J D, Brand M D
机构信息
Department of Biochemistry, University of Cambridge, U.K.
出版信息
Biochem J. 1989 Jan 1;257(1):285-8. doi: 10.1042/bj2570285.
Abstract
- In the presence of physiological concentrations of Na+ and Mg2+, the rate of citrulline synthesis by isolated rat liver mitochondria respiring on a range of substrates was stimulated by up to 60% when the extramitochondrial Ca2+ concentration was raised from 130 pM to 770 nM. 2. Our findings suggest that hormonal stimulation of the urea cycle may be mediated by Ca2+.
摘要
- 在存在生理浓度的Na+和Mg2+的情况下，当线粒体外Ca2+浓度从130皮摩尔升至770纳摩尔时，分离的大鼠肝脏线粒体在一系列底物上进行呼吸作用时，瓜氨酸合成速率最多可提高60%。2. 我们的研究结果表明，尿素循环的激素刺激可能由Ca2+介导。
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Glucagon: a protein catabolic hormone in the isolated perfused rat liver.胰高血糖素：分离灌注大鼠肝脏中的一种蛋白质分解代谢激素。
Nature. 1960 Jan 23;185:248. doi: 10.1038/185248a0.
2
Hormonal effects on calcium homeostasis in isolated hepatocytes.激素对分离肝细胞钙稳态的影响。
J Biol Chem. 1980 Jul 25;255(14):6600-8.
3
Energetics of citrulline synthesis by rat liver mitochondria.大鼠肝脏线粒体合成瓜氨酸的能量学
J Biol Chem. 1981 Jul 25;256(14):7287-97.
4
Relationship between the rate of citrulline synthesis and bulk changes in the intramitochondrial ATP/ADP ratio in rat-liver mitochondria.大鼠肝脏线粒体中瓜氨酸合成速率与线粒体内ATP/ADP比值整体变化之间的关系。
Eur J Biochem. 1981 Jan;113(2):295-302. doi: 10.1111/j.1432-1033.1981.tb05066.x.
5
Vasopressin and angiotensin II stimulate ureogenesis through increased mitochondrial citrulline production.血管加压素和血管紧张素II通过增加线粒体瓜氨酸生成来刺激尿素生成。
Life Sci. 1982 Nov 29;31(22):2493-8. doi: 10.1016/0024-3205(82)90755-x.
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Acute effects of glucagon on citrulline biosynthesis.胰高血糖素对瓜氨酸生物合成的急性影响。
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