Gankina E M, Moskvitina T A, Gorkin V Z, Val'dman A V
Biull Eksp Biol Med. 1982 Nov;94(11):29-31.
The effect of different antidepressants (MAO inhibitors, monoamine uptake inhibitors, new drugs) on the activity of bovine brain monoamine oxidase was investigated. The type A MAO activity was found to be selectively inhibited by the morpholine derivative, moclobamide (IC50-10(-5) M). Pyrazidol, inkazan, imipramine, and iproniazide also had an inhibitory effect on the enzyme activity, but their action was not selective. Zymelidine and norzymelidine (10(-4) M) slightly reduced the deamination of serotonin and 2-phenylalanine. The hydrazine derivatives, N 33 and N 34 showed the same effects. The morpholine derivative, viloxazine had no effect on the MAO activity of bovine brain. It is inferred that not only classic MAO inhibitors but also antidepressants of different structure are capable of inhibiting brain monoamine oxidase.
研究了不同抗抑郁药（单胺氧化酶抑制剂、单胺摄取抑制剂、新药）对牛脑单胺氧化酶活性的影响。发现吗啉衍生物吗氯贝胺（IC50 - 10(-5) M）可选择性抑制A型单胺氧化酶活性。吡唑醇、因卡赞、丙咪嗪和异烟肼也对该酶活性有抑制作用，但它们的作用不具有选择性。齐美利定和去甲齐美利定（10(-4) M）可轻微降低血清素和2 - 苯丙氨酸的脱氨基作用。肼衍生物N 33和N 34表现出相同的效果。吗啉衍生物维洛沙嗪对牛脑单胺氧化酶活性无影响。据推断，不仅经典的单胺氧化酶抑制剂，而且不同结构的抗抑郁药都能够抑制脑单胺氧化酶。
