[Mechanism of decreased oxygen tension in tissue during hyperoxia and criteria of hyperoxygenation dosage].

Experiments on white rats were made to study the effect of normo- and hyperbaric oxygenation on the total oxygen consumption, its tension in tissues, and the course of oxidative processes in liver mitochondrial preparations from animals exposed to oxygen under positive pressure. It was found that the time of the development of the protective reaction to hyperoxia in the mitochondria was in agreement with the onset of a progressive fall of oxygen tension in the tissues. Experiments with hyperbaric oxygenation in the presence of artificial inhibition or stimulation of the oxidative processes in the body demonstrated a pathogenic relationship between the fall of oxygen tension in the tissues and intensification of its recovery in the mitochondria. The recommendations are given as to the use of the results obtained for the elaboration of more effective regimens of oxygen therapy.