Mower G D, Burchfiel J L, Duffy F H
Brain Res. 1982 Nov;281(3):311-27. doi: 10.1016/0165-3806(82)90130-4.
Receptive field properties of visual cortical and lateral geniculate cells were studied in 4 models of amblyopia in the cat: monocular deprivation (MD cats), surgical esotropia (esotropic cats), optically induced concomitant strabismus (stationary prism cats) and optically induced incomitant strabismus (rotating prism cats). Comparison observations were made in normal cats. Recordings in visual cortex indicated a reduction in responsiveness to the treated eye in MD and rotating prism cats. Esotropic and stationary prism cats showed mainly a loss of binocular cells. Recordings in the lateral geniculate nucleus indicated a reduction in the spatial resolving capacity of X-cells driven by the treated eye in MD, esotropic and rotating prism cats. The magnitude of this effect was comparable in all of these preparations. Stationary prism cats showed comparable spatial resolving capacities in X-cells driven by either eye. Y-cells were unaffected in any preparation except MD where there were reduced frequencies of Y-cells driven by the treated eye. These results indicate that: (1) interocular differences in spatial patterns without form deprivation are sufficient to produce a loss of responsiveness to one eye in visual cortex; (2) incomitant disparities are necessary to produce the physiological correlates of amblyopia in cats; and (3) deficits in spatial resolution in geniculate neurons are comparable in magnitude in various amblyopic preparations.
在猫的4种弱视模型中研究了视皮层和外侧膝状体细胞的感受野特性：单眼剥夺（MD猫）、手术性内斜视（内斜视猫）、光学诱导的共同性斜视（固定棱镜猫）和光学诱导的非共同性斜视（旋转棱镜猫）。在正常猫中进行了对照观察。视皮层记录显示，MD猫和旋转棱镜猫对治疗眼的反应性降低。内斜视猫和固定棱镜猫主要表现为双眼细胞丧失。外侧膝状体核记录显示，MD猫、内斜视猫和旋转棱镜猫中，由治疗眼驱动的X细胞的空间分辨能力降低。在所有这些实验准备中，这种效应的程度相当。固定棱镜猫中，由任一眼驱动的X细胞的空间分辨能力相当。除MD猫外，Y细胞在任何实验准备中均未受影响，MD猫中由治疗眼驱动的Y细胞频率降低。这些结果表明：（1）无形式剥夺的空间模式的眼间差异足以导致视皮层对一只眼的反应性丧失；（2）非共同性差异是猫弱视生理相关因素产生所必需的；（3）在各种弱视实验准备中，膝状体神经元的空间分辨率缺陷程度相当。
