Assael B M, Banfi G, Appiani A C, Edefonti A, Jusko W J
Eur J Clin Pharmacol. 1982;23(5):429-33. doi: 10.1007/BF00605993.
The disposition of a large pulse-dose of methylprednisolone was examined in paediatric and adult patients with the nephrotic syndrome. Plasma concentrations and urinary excretion rates were measured by high performance liquid chromatography. Most of the dose was metabolized, as indicated by urinary recovery of less than 10 percent of the dose. There was only slight age-dependence of the plasma clearance and volume of distribution of the steroid, although the T1/2 and mean transit time were shorter in younger patients. The pharmacokinetic parameters of the large doses (12-20 mg/kg) were similar to low dose (0.5-1 mg/kg) data from asthmatic patients. The limited variability of the pharmacokinetics of methylprednisolone suggests that tissue sensitivity may be a more important indicator of drug dosage needs in nephrotic syndrome.
对患有肾病综合征的儿科和成年患者给予大脉冲剂量甲泼尼龙后，研究了其处置情况。采用高效液相色谱法测定血浆浓度和尿排泄率。如尿中回收剂量不到10%所示，大部分剂量被代谢。尽管年轻患者的半衰期和平均通过时间较短，但类固醇的血浆清除率和分布容积仅有轻微的年龄依赖性。大剂量（12 - 20mg/kg）的药代动力学参数与哮喘患者低剂量（0.5 - 1mg/kg）的数据相似。甲泼尼龙药代动力学的有限变异性表明，组织敏感性可能是肾病综合征中药物剂量需求的一个更重要指标。
