[Effect of barbiturates on the respiratory activity of rat liver microsomes].

Administration to white rats of phenobarbital, benzonal and benzobamyl in a dose of 1/20 LD50 for 4--14 days was accompanied by enhanced respiration of microsomes isolated from liver tissue, by acceleration of NAD.H and NADP.H oxidation, by activation of amidopyrin and hexobarbital metabolism, by an increase in the hepatocyte content of P 450 and b5. Administration of the drug during one month entails the normalization of microsomal respiration and the hemoprotein content.