Wakusawa S, Miyamoto K, Koshiura R
Gan. 1982 Aug;73(4):637-41.
The influence of two antidepressants, iproniazid and imipramine, was examined on the antileukemic combination effect of reserpine with 1-gamma-chloropropyl-2-chloromethylpiperidine hydrobromide (CAP-2), mitomycin C, or vinblastine on L1210. While reserpine synergistically increased the life span at the dose of 2.5 mg/kg in combination with these antitumor agents, the mice given reserpine showed considerable reduction of food intake and hypothermia. Iproniazid reduced all these effects of reserpine, while imipramine slightly potentiated hypothermia among these effects of reserpine. Starvation scarcely influenced the effect of the antitumor agents. On the other hand, reserpine also enhanced the antiproliferating effect of CAP-2 against L1210 cells in vitro. Iproniazid did not influence the combined antiproliferating effect of these agents in vitro. These results indicate that iproniazid reduced the antileukemic combination effect of reserpine with antitumor agents through an antireserpic effect such as inhibition of hypothermia. Therefore, it seems likely that the antileukemic combination effect of reserpine is closely related to the marked hypothermia, and only partially related to the direct effect on L1210 cells.
研究了两种抗抑郁药异烟肼和丙咪嗪对利血平与1-γ-氯丙基-2-氯甲基哌啶氢溴酸盐（CAP-2）、丝裂霉素C或长春碱联合对L1210白血病细胞的抗白血病联合效应的影响。虽然利血平在2.5mg/kg剂量与这些抗肿瘤药物联合使用时能协同延长生存期，但给予利血平的小鼠食物摄入量显著减少且体温过低。异烟肼减轻了利血平的所有这些效应，而丙咪嗪在利血平的这些效应中略微增强了体温过低的情况。饥饿几乎不影响抗肿瘤药物的效果。另一方面，利血平在体外也增强了CAP-2对L1210细胞的抗增殖作用。异烟肼不影响这些药物在体外的联合抗增殖作用。这些结果表明，异烟肼通过抗利血平作用如抑制体温过低来降低利血平与抗肿瘤药物的抗白血病联合效应。因此，利血平的抗白血病联合效应似乎与明显的体温过低密切相关，而仅部分与对L1210细胞的直接作用有关。
