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受刺激、未受刺激和抑制的外分泌汗腺中的细胞内钙定位。

Intracellular calcium localization in stimulated, non-stimulated and repressed eccrine sweat glands.

作者信息

Sampson H W, Bowers D E

出版信息

J Anat. 1982 Oct;135(Pt 3):565-75.

Abstract

Acinar cells of eccrine sweat glands from control, pilocarpine-treated, and atropine-treated rats were studied using a potassium pyroantimonate technique for calcium localization at the ultrastructural level. This was done in order to identify intracellular compartmentalization of calcium and to elucidate any calcium translocation that might occur during the secretion process. Calcium-pyroantimonate complexes were identified in the mitochondria, plasma membrane and cytoplasmic vesicles of the untreated and the atropine-treated specimens. These complexes decreased drastically in the actively secreting cells. The function of calcium in sweat gland secretion and the action of the utilized pharmacological agents on membrane calcium are discussed.

摘要

利用焦锑酸钾技术在超微结构水平对正常对照组、毛果芸香碱处理组和阿托品处理组大鼠的外分泌汗腺腺泡细胞进行钙定位研究。这样做是为了确定钙在细胞内的区室化分布,并阐明分泌过程中可能发生的任何钙转运情况。在未处理组和阿托品处理组标本的线粒体、质膜和细胞质小泡中发现了焦锑酸钙复合物。在活跃分泌的细胞中,这些复合物显著减少。文中讨论了钙在汗腺分泌中的作用以及所用药物对膜钙的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2658/1169405/24a091d26665/janat00215-0115-a.jpg

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