Lea A R, Hailey D M, Duguid P R
J Chromatogr. 1982 Nov 26;250:35-42. doi: 10.1016/s0021-9673(00)95207-5.
A high-performance liquid-chromatographic (HPLC) method for the determination of haloperidol in tablets was developed and evaluated by an inter-laboratory study. The spectrophotometric method of the British Pharmacopoeia 1973 was evaluated concurrently, and the accuracy and precision of the methods were compared. Two samples of a commercially available haloperidol tablet formulation were analysed by thirteen laboratories with satisfactory results for column performance and precision of assay. The total error standard deviations, SD, for the HPLC method and the spectrophotometric method were 3.92 and 2.58%, respectively. The HPLC method is considered suitable for official testing purposes.
建立了一种用于测定片剂中氟哌啶醇的高效液相色谱（HPLC）法，并通过实验室间研究进行了评估。同时对1973年版《英国药典》中的分光光度法进行了评估，并比较了这两种方法的准确性和精密度。13个实验室对市售氟哌啶醇片剂制剂的两个样品进行了分析，柱性能和测定精密度结果令人满意。HPLC法和分光光度法的总误差标准偏差（SD）分别为3.92%和2.58%。HPLC法被认为适用于官方检测目的。
