Sengoku K, Ishikawa M, Yamashita K, Mizoguchi H, Kasamo M, Shimizu T, Tanaka K
Nihon Sanka Fujinka Gakkai Zasshi. 1982 Dec;34(12):2205-11.
The relation between ultrasonographic signs of ovulation and serum estradiol (E2) rise and luteinizing hormone (LH) surge were studied. Forty-eight cycles were examined in Twenty-eight infertile patients. The correlation between the follicular diameter as measured by ultrasound and actual follicular diameter under direct visualization was also determined in 19 follicles of the 25 patients who had undergone laparotomy. In 34 of the 48 cycles, growing follicles and follicular rupture could be observed by ultrasound (72.3%). The mean diameter of the follicles measured the day before estimated ovulation was 22.4 +/- 2.75 mm(range 16-27mm). The ultrasonographic ovulation period (UOP) occurred within 24 hours from the day of maximal LH levels in 24 of the 34 cycles, and within 48 hours from the day of the E2 peak in 25 of the 34 cycles. The follicular diameter measured by ultrasound was greater than the actual diameter found during laparotomy, but there was a high degree of correlation (r = 0.900). Furthermore, the E2 and P levels in follicular fluid were high in large follicles and correlated well with the ultrasound assessments of follicular size. These results suggested that ultrasonic monitoring provides a reliable measure of follicular growth and prediction of ovulation, and offers a highly sophisticated scientific tool for the study of reproductive endocrinology.
研究了排卵的超声征象与血清雌二醇（E2）升高及促黄体生成素（LH）峰之间的关系。对28例不孕患者的48个周期进行了检查。还对25例接受剖腹手术患者的19个卵泡进行了超声测量卵泡直径与直视下实际卵泡直径之间的相关性测定。在48个周期中的34个周期（72.3%），超声可观察到卵泡生长和卵泡破裂。预计排卵前一天测量的卵泡平均直径为22.4±2.75mm（范围16 - 27mm）。在34个周期中的24个周期，超声排卵期（UOP）在LH水平最高之日起24小时内出现，在34个周期中的25个周期，在E2峰值之日起48小时内出现。超声测量的卵泡直径大于剖腹手术中发现的实际直径，但两者具有高度相关性（r = 0.900）。此外，大卵泡中卵泡液中的E2和P水平较高，且与卵泡大小的超声评估相关性良好。这些结果表明，超声监测为卵泡生长和排卵预测提供了可靠的测量方法，并为生殖内分泌学研究提供了一种高度精密的科学工具。
