布美他尼在正常受试者中的药代动力学和药效学。

The pharmacokinetics and pharmacodynamics of bumetanide in normal subjects.

作者信息

Marcantonio L A, Auld W H, Skellern G G, Howes C A, Murdoch W R, Purohit R

出版信息

J Pharmacokinet Biopharm. 1982 Aug;10(4):393-409. doi: 10.1007/BF01065171.

Abstract

The pharmacokinetics and pharmacodynamics of bumetanide (1 mg) administered either orally or intravenously were studied in a group of normal subjects using high-pressure liquid chromatography. A two-compartment model adequately fitted the intravenous data. Renal clearance (85 ml min-1) contributed 65% to the total elimination of bumetanide irrespective of whether a model-dependent or model-independent method was used. Oral administration of bumetanide elicited a greater and a more prolonged pharmacological response than did intravenous bumetanide. An attempt is made to relate the pharmacokinetics of the drug to its pharmacodynamics.

摘要

在一组正常受试者中，使用高压液相色谱法研究了口服或静脉注射布美他尼（1毫克）的药代动力学和药效学。二室模型能很好地拟合静脉注射数据。无论采用模型依赖法还是模型非依赖法，肾清除率（85毫升/分钟）对布美他尼总清除率的贡献率均为65%。与静脉注射布美他尼相比，口服布美他尼引起的药理反应更强且更持久。本文尝试将该药物的药代动力学与其药效学联系起来。