Brater D C, Chennavasin P
J Clin Pharmacol. 1981 Jul;21(7):311-5. doi: 10.1002/j.1552-4604.1981.tb01772.x.
We administered 0.5-and 1.0-mg doses of bumetanide intravenously to eight normal subjects with and without pretreatment with probenecid. Probenecid did not effect either the cumulative response or the time course of response of bumetanide. These results are in contrast to results reported in dogs but consistent with similar studies in cats. The data imply that probenecid and potentially other exogenous or endogenous organic acids do not affect the renal handling of bumetanide in normal man.
我们对8名正常受试者静脉注射0.5毫克和1.0毫克剂量的布美他尼，其中部分受试者预先使用了丙磺舒，部分未使用。丙磺舒对布美他尼的累积反应或反应的时间进程均无影响。这些结果与在狗身上报道的结果相反，但与在猫身上进行的类似研究结果一致。数据表明，丙磺舒以及其他可能的外源性或内源性有机酸不会影响正常人体内布美他尼的肾脏处理过程。
