Castleden C M, Duffin H M, Briggs R S, Ogden B M
J Urol. 1982 Dec;128(6):1250-2. doi: 10.1016/s0022-5347(17)53448-5.
The effect of ephedrine, an adrenergic receptor agonist, was investigated in 24 elderly patients with urinary incontinence associated with unstable detrusor contractions. After 3 weeks of oral ephedrine repeat cystometry showed mean increases of 21 per cent in bladder capacity and of 23 per cent in urethral pressure. Of 21 patients studied 7 became continent and 12 were improved. However, the urodynamic improvement did not reach statistical significance even in the continent group and, thus, the clinical improvement was unlikely to be owing to ephedrine. Therefore, open studies of drug treatment for detrusor instability may be misleading unless clinical and cystometric data are obtained.
对24例伴有逼尿肌不稳定收缩所致尿失禁的老年患者，研究了肾上腺素能受体激动剂麻黄碱的疗效。口服麻黄碱3周后，重复膀胱测压显示膀胱容量平均增加21%，尿道压力平均增加23%。在接受研究的21例患者中，7例尿失禁症状消失，12例有所改善。然而，即使在尿失禁症状消失的患者组中，尿动力学改善也未达到统计学显著性，因此，临床症状的改善不太可能是麻黄碱所致。所以，除非获得临床和膀胱测压数据，否则对逼尿肌不稳定进行药物治疗的开放性研究可能会产生误导。
