Successful treatment of male infertility caused by antispermatozoal antibodies.

Spermatozoa in the ejaculate of a man with antispermatozoal antibodies in the serum (gelatin agglutination technique (GAT) titre, 640) and the seminal plasma (GAT titre, 80) were shown to have IgG and IgA bound to them. In preparation for intrauterine artificial insemination, the ejaculate was collected in Tyrode's medium. Then spermatozoa were washed, resuspended in Tyrode's medium, and 0.2 mL of the suspension was injected in the uterus. A successful pregnancy resulted. Reasons are given for considering that the successful pregnancy resulted from the manipulation of the semen.