Aubert P, Chaignon M, Leguy P, Delbart H, Lucsko M, Guedon J
Nephrologie. 1982;3(4):171-5.
Hemodialysis has been reported to produce a decrease in cardiac output partially related to a peripheral relocation of blood volume. In order to further evaluate this hypothesis, the hemodynamic effects of dihydroergotamine (DHE), a veino-constrictor drug, were investigated in 5 patients undergoing hemodialysis. Body weight, total blood volume, arterial blood pressure, cardiac output and heart rate were obtained before (period A) and immediately after hemodialysis: before (period B) and after an acute infusion of DHE (period C); studies were performed in supine then in tilted position. During period B, cardiac index decreased by 27% (p less than 0.05) and stroke index by 35% (p less than 0.02). Acute infusion of DHE produced a significant increase in cardiac index (+ 18%, p less than 0.05), stroke index (+ 28%, p less than 0.05) and blood pressure (+ 20%, p less than 0.05). These results indicate that the hemodynamic alterations induced by hemodialysis may be partially reversed by contraction of the capacitance system following DHE infusion.
据报道，血液透析会导致心输出量下降，部分原因与血容量向外周重新分布有关。为了进一步评估这一假设，对5例接受血液透析的患者研究了静脉收缩药双氢麦角胺（DHE）的血流动力学效应。在血液透析前（A期）和透析结束后即刻获取体重、总血容量、动脉血压、心输出量和心率：在急性输注DHE前（B期）和输注后（C期）进行研究；研究在仰卧位然后在倾斜位进行。在B期，心脏指数下降27%（p<0.05），每搏指数下降35%（p<0.02）。急性输注DHE使心脏指数显著增加（+18%，p<0.05）、每搏指数增加（+28%，p<0.05）以及血压升高（+20%，p<0.05）。这些结果表明，血液透析引起的血流动力学改变可能通过输注DHE后容量系统的收缩而部分逆转。
