Goudie A J, Buckland C
Neuropharmacology. 1982 Dec;21(12):1267-72. doi: 10.1016/0028-3908(82)90131-9.
The 5-hydroxytryptamine (5HT) receptor blocker, methysergide (10 mg/kg), was found to potentiate the behavioural effects of beta-phenylethylamine (PEA) (at doses between 20 and 60 mg/kg) on food reinforced schedule-maintained behaviour in two separate experiments involving a fixed interval 2 min schedule and a fixed ratio 20 schedule. Potentiation caused a parallel shift to the left in the log dose response curve for suppression of responding induced by phenylethylamine, and was observed in both male and female rats. These data contrast with recent reports indicating that inhibition of functioning of 5HT systems blocks the effects of phenylethylamine in inducing the "Serotonin behavioural syndrome" (Sloviter et al., 1980a: Dourish, 1981). However, the potentiation reported here is compatible with frequent reports indicating that behavioural effects of amphetamine (alpha-methyl-PEA) can be potentiated by reduction in 5HT functioning and are thus compatible with the hypothesis that phenylethylamine is a potential "endogenous amphetamine".
在两项分别涉及固定间隔2分钟程序和固定比率20程序的独立实验中，发现5-羟色胺（5HT）受体阻滞剂麦角酸二乙酰胺（10毫克/千克）可增强β-苯乙胺（PEA）（剂量在20至60毫克/千克之间）对食物强化的按时间表维持行为的行为学效应。这种增强作用导致苯乙胺诱导反应抑制的对数剂量反应曲线向左平行移动，并且在雄性和雌性大鼠中均观察到。这些数据与最近的报告形成对比，那些报告表明5HT系统功能的抑制会阻断苯乙胺诱导“血清素行为综合征”的效应（斯洛维特等人，1980年a：多拉什，1981年）。然而，此处报告的增强作用与频繁的报告相符，那些报告表明5HT功能的降低可增强苯丙胺（α-甲基-PEA）的行为学效应，因此与苯乙胺是潜在“内源性苯丙胺”的假设相符。
