Thauvin C, Borsa F, Leroy A, Humbert G
Nouv Presse Med. 1982 Nov 18;11(46):3410-3.
The principal pharmacokinetic parameters of dibekacin were studied in five adult subjects with normal renal function after IM and IV injection of a single dose of 1 mg/kg. The results obtained showed that the pharmacokinetics of dibekacine were independent of the dose (T1/2: 2.1 h; distribution volume: 14-161; renal clearance: congruent to 70 ml/min; urinary excretion in 24 hours congruent to 80%) and very similar to those of other aminoglycosides of the deoxystreptamine group.
在5名肾功能正常的成年受试者中，单次肌内注射和静脉注射1mg/kg剂量的地贝卡星后，研究了其主要药代动力学参数。所得结果表明，地贝卡星的药代动力学与剂量无关（半衰期：2.1小时；分布容积：14 - 161；肾清除率：约70ml/分钟；24小时尿排泄率：约80%），且与其他脱氧链霉胺类氨基糖苷类药物非常相似。
