Araya O, Ford E J
Q J Exp Physiol. 1982 Oct;67(4):513-9. doi: 10.1113/expphysiol.1982.sp002671.
Single intravenous injections of bromosulphthalein (BSP) were given to calves before and at intervals after the oral administration of 1000 metacercariae of Fasciola hepatica. The change in BSP concentration with time was analysed by computer to obtain the proportion of BSP extracted from plasma by hepatic cells (E) and the rate of hepatic blood flow (F). The increasing age of the normal calves during the 34 weeks of experiment had no significant effect on E or F. There was no significant effect of the duration of the fasciola lesion on E or F. When all tests on infected calves were compared as a group with tests on uninfected calves, there was a significant reduction in E(P less than 0.05) and in F(P less than 0.001) in the calves infected with F. hepatica. A survey of previously reported results suggests that sheep and cattle have a wide range of F values and that F is probably lower in 3-month-old calves than in adult cattle.
在口服1000只肝片吸虫的囊蚴之前和之后的不同时间间隔，给小牛单次静脉注射酚四溴酞磺酸钠（BSP）。通过计算机分析BSP浓度随时间的变化，以获得肝细胞从血浆中提取BSP的比例（E）和肝血流量（F）。在34周的实验过程中，正常小牛年龄的增长对E或F没有显著影响。肝片吸虫病变的持续时间对E或F也没有显著影响。当将感染小牛的所有测试作为一组与未感染小牛的测试进行比较时，感染肝片吸虫的小牛的E（P小于0.05）和F（P小于0.001）显著降低。对先前报道结果的一项调查表明，绵羊和牛的F值范围很广，并且3月龄小牛的F值可能低于成年牛。
