Legrand C, Clos J, Legrand J
Reprod Nutr Dev (1980). 1982;22(1B):201-8. doi: 10.1051/rnd:19820206.
On day of birth, the synaptic density of the rat cerebellar cortex in experimental, as compared to control, rats was slightly reduced or increased, respectively, after propylthiouracil treatment of the dam or thyroxine injection of the fetus. The stimulation of synaptogenesis in thyroxine-treated neonates was particularly obvious at the level of the ganglionic layer containing Purkinje cell bodies and was accompanied at the same level by accelerated growth of the presynaptic endings and perisomatic processes of the Purkinje cells. Undernourishment of the dam from day 6 of gestation led to an unexpected stimulation of synaptogenesis in the cerebellar cortex of the neonates; synaptic density was significantly increased above the normal value and much more markedly than in the thyroxine-treated neonates, but there was no abnormal proliferation of the neuronal processes. Different mechanisms underlay the transient stimulation of synaptogenesis in these two conditions. These results have been related to the disturbances in the development of Bergmann glia previously found soon after birth in altered thyroid and nutritional states.
在出生当天，对孕鼠进行丙硫氧嘧啶处理或对胎儿注射甲状腺素后，与对照大鼠相比，实验大鼠小脑皮质的突触密度分别略有降低或增加。甲状腺素处理的新生儿突触发生的刺激在含有浦肯野细胞体的神经节层水平尤为明显，并且在同一水平上伴随着浦肯野细胞突触前末梢和胞体周围突起的加速生长。从妊娠第6天开始对孕鼠进行营养不良处理，导致新生儿小脑皮质突触发生意外刺激；突触密度显著高于正常值，且比甲状腺素处理的新生儿更为明显，但神经元突起没有异常增殖。这两种情况下突触发生的短暂刺激有不同的机制。这些结果与出生后不久在甲状腺和营养状态改变时发现的伯格曼胶质细胞发育紊乱有关。
