Davicco M J, Lefaivre J, Barlet J P
Reprod Nutr Dev (1980). 1982;22(3):557-67. doi: 10.1051/rnd:19820411.
Plasma thyroxine (T4) and triiodothyronine (T3) levels were measured in 7 pregnant ewes and their 9 chronically cannulated foetuses during the last 37 days of gestation and the first 5 days after parturition. The highest plasma T4 and T3 levels were measured in lambs during the hours following parturition. In 7 chronically cannulated 139-day old foetal lambs, the intravenous injection of ovine thyrotropin (oTSH; 7 mU per foetus) induced a significantly more intense increase in plasma T4 and T3 levels than that observed after the same dose of oTSH in seven 130-day old foetuses. In newborn lambs, the increase in plasma T4 levels after oTSH injection (3.5 mU per kg body weight) was not different in 8-hour old and 36-hour old animals, but was more intense at 120 h after birth than at 8 or 36 h after birth. The rise in plasma T3 levels after oTSH increased with age at 8, 36 and 120 h following birth. Plasma T4 and T3 measurements made in the same lambs before and after birth confirmed the fragmentary values obtained in foetal and newborn lambs in other previous studies. The rise in plasma iodothyronine levels after TSH injection in lambs increased at the end of gestation and the beginning of neonatal life, except during the first hours after delivery when these levels were high.
在妊娠的最后37天和分娩后的前5天，对7只怀孕母羊及其9只长期插管的胎儿测量了血浆甲状腺素（T4）和三碘甲状腺原氨酸（T3）水平。在羔羊分娩后的数小时内测得血浆T4和T3的最高水平。在7只长期插管的139日龄胎儿羔羊中，静脉注射羊促甲状腺素（oTSH；每只胎儿7 mU）后，血浆T4和T3水平的升高幅度明显大于7只130日龄胎儿注射相同剂量oTSH后观察到的升高幅度。在新生羔羊中，注射oTSH（每千克体重3.5 mU）后，8小时龄和36小时龄动物的血浆T4水平升高无差异，但出生后120小时比出生后8小时或36小时更为明显。出生后8、36和120小时，oTSH注射后血浆T3水平的升高随年龄增长。对同一只羔羊在出生前后进行的血浆T4和T3测量证实了之前其他研究中在胎儿和新生羔羊中获得的不完整数据。除分娩后的最初几个小时这些水平较高外，在妊娠末期和新生儿期开始时，羔羊注射TSH后血浆碘甲状腺原氨酸水平的升高幅度增加。
