非肾上腺素能抑制性神经系统在气道高反应性中的可能作用。

A possible role of a nonadrenergic inhibitory nervous system in airway hyperreactivity.

作者信息

Aizawa H, Matsuzaki Y, Ishibashi M, Domae M, Hirose T, Shigematsu N, Tanaka K

出版信息

Respir Physiol. 1982 Nov;50(2):187-96. doi: 10.1016/0034-5687(82)90017-2.

Abstract

To investigate a possible role of a nonadrenergic inhibitory nervous system in airway hyperreactivity, we measured changes in RL and CL caused by electrical stimulation of cervical vagus nerve during the infusion of 5-HT, after treatment with atropine and propranolol in 18 cats. RL decreased to 56 +/- 3% (mean +/- SE) and CL increased to 186 +/- 13% of the prestimulated values, respectively, after stimulation. Hexamethonium diminished these responses significantly. Airway reactivity to 5-HT was reduced by continuous electrical stimulation of cervical vagus nerve in cats pretreated with atropine and propranolol. Hexamethonium potentiated airway reactivity to 5-HT. These results suggest that a nonadrenergic inhibitory nervous system could play an important role in the control of the bronchomotor tone and contribute to airway hyperreactivity.

摘要

为了研究非肾上腺素能抑制性神经系统在气道高反应性中可能发挥的作用，我们在18只猫中，于输注5-羟色胺期间、给予阿托品和普萘洛尔治疗后，测量了颈迷走神经电刺激引起的气道阻力（RL）和顺应性（CL）的变化。刺激后，RL分别降至刺激前值的56±3%（平均值±标准误），CL升至刺激前值的186±13%。六甲铵显著减弱了这些反应。在预先用阿托品和普萘洛尔处理的猫中，颈迷走神经的持续电刺激降低了气道对5-羟色胺的反应性。六甲铵增强了气道对5-羟色胺的反应性。这些结果表明，非肾上腺素能抑制性神经系统可能在支气管运动张力的控制中发挥重要作用，并导致气道高反应性。