Jochimsen P R, Ness S J, Sherman B M
Surg Gynecol Obstet. 1978 Dec;147(6):842-4.
It is clear that a variety of metastatic deposits can successfully be assayed and found to contain estrogen receptor protein even up to 13 years following the initial tumor surgical procedure. Whether or not the patient has received previous treatment, estrogen receptor status does not appear to be influenced, and biopsies of the 23 metastatic lesions were found to contain estrogen receptors. Fourteen of nineteen patients with metastatic tumors containing estrogen receptors who were treated and evaluated demonstrated remission after hormonal manipulation. Only one patient with a tumor with no estrogen receptors demonstrated tumor regression after hypophysectomy and suggests that a previous response to hormone manipulation may warrant a further trial even when estrogen receptors are not found. The results of estrogen receptor values on metastatic disease of the breasts are extremely valuable in the therapeutic decision making process and should be routinely obtained.
很明显，即使在初次肿瘤手术操作后长达13年，各种转移性沉积物仍可成功检测并发现含有雌激素受体蛋白。无论患者先前是否接受过治疗，雌激素受体状态似乎都不受影响，对23个转移性病变的活检发现含有雌激素受体。19例转移性肿瘤含有雌激素受体的患者中，有14例接受治疗和评估后经激素处理出现缓解。只有1例肿瘤无雌激素受体的患者在垂体切除术后出现肿瘤消退，这表明即使未发现雌激素受体，先前对激素处理的反应可能仍值得进一步试验。乳腺癌转移性疾病的雌激素受体值结果在治疗决策过程中极具价值，应常规获取。
