北美纳瓦霍印第安人的HLA同种抗原研究。II. HLA - A、B、C、DR及其他遗传标记

Study of HLA alloantigens of the Navajo Indians of North America. II. HLA-A, B, C, DR and other genetic markers.

作者信息

Troup G M, Schanfield M S, Singaraju C H, Harvey R L, Jameson J, Capper J, Baker B

出版信息

Tissue Antigens. 1982 Nov;20(5):339-51. doi: 10.1111/j.1399-0039.1982.tb02250.x.

DOI:10.1111/j.1399-0039.1982.tb02250.x

Abstract

This report presents the antigen frequencies for HLA-A, B, C, DR, immunoglobulin, and red blood cell systems for the Navajo Indians of North America. HLA-A-B,B-C, and B-DR haplotype frequencies and significant delta values are given. These data are compared with similar data for other American Indians and major non-Indian ethnic groups. Very restricted HLA polymorphism is unique for the Navajo as well as American Indians in general and this feature has important implications with regard to disease association and transplantation.

摘要

本报告展示了北美纳瓦霍印第安人的HLA - A、B、C、DR、免疫球蛋白和红细胞系统的抗原频率。给出了HLA - A - B、B - C和B - DR单倍型频率以及显著的δ值。这些数据与其他美洲印第安人和主要非印第安种族群体的类似数据进行了比较。非常有限的HLA多态性是纳瓦霍人以及一般美洲印第安人的独特特征，这一特征在疾病关联和移植方面具有重要意义。