植物结合甲基汞对大鼠体内其分布、排泄及脱甲基模式的影响。

The effects of plant-incorporated methylmercury on its distribution, excretion and demethylation patterns in the rat.

作者信息

Czuba M, Komsta-Szumska E, Mortimer D C, Reuhl K R

出版信息

Toxicol Lett. 1982 Nov;14(1-2):15-20. doi: 10.1016/0378-4274(82)90004-2.

Abstract

Rats were dosed once per os with either plant-incorporated or solution-radioactive methylmercury (MeHg). While whole-body retention did not change, the incorporation into some organs was approx. 2.5 X higher when administered Hg was in the plant-incorporated rather than in solution form. The only noticeable change in demethylation occurred in the cerebrum where MeHg:Hg ratios were 79:10 (plant-incorporated MeHg) and 65:24 (solution-MeHg). Between 5 to 7% of the total mercury was excreted in faeces and urine either in the inorganic (faeces) or organic (urine) forms. Mercury levels in mitochondrial and soluble fractions of cerebrum were noticeably lower with plant-MeHg than with solution-MeHg.

摘要

大鼠经口一次性给予植物结合态或溶液态放射性甲基汞（MeHg）。虽然全身汞潴留量没有变化，但当给予的汞为植物结合态而非溶液态时，某些器官中的汞掺入量约高2.5倍。脱甲基作用中唯一明显的变化发生在大脑中，其中甲基汞与汞的比例分别为79:10（植物结合态甲基汞）和65:24（溶液态甲基汞）。总汞的5%至7%以无机（粪便）或有机（尿液）形式经粪便和尿液排出。与溶液态甲基汞相比，植物甲基汞组大脑线粒体和可溶性部分中的汞含量明显较低。