Krian A, Bircks W, Schulte H D
Thoraxchir Vask Chir. 1978 Oct;26(5):325-30. doi: 10.1055/s-0028-1096647.
In 342 patients undergoing open heart surgery we determined the serum enzyme levels of GOT, GPT, LDH, alpha-HBDH, LAP, CK and CK-MB from the beginning of the operation up to the 14 th postoperative day. There was an elevation of serum enzymes depending on the type of operation, the duration of extracorporal circulation and the postoperative course. A pattern of enzyme changes for uncomplicated cases is described. The investigations demonstrate a statistically significant correlation between the elevation of "liver specific enzymes" and right heart failure on one hand and of "heart specific enzymes" and myocardial ischemia on the other hand. It is concluded that only repeated determinations beginning with the operation enable to evaluate serum enzyme levels.
在342例接受心脏直视手术的患者中,我们测定了从手术开始至术后第14天血清中谷草转氨酶(GOT)、谷丙转氨酶(GPT)、乳酸脱氢酶(LDH)、α-羟丁酸脱氢酶(α-HBDH)、亮氨酸氨基肽酶(LAP)、肌酸激酶(CK)和肌酸激酶同工酶(CK-MB)的水平。血清酶水平会根据手术类型、体外循环时间和术后病程而升高。文中描述了非复杂病例的酶变化模式。研究表明,一方面“肝脏特异性酶”升高与右心衰竭之间,另一方面“心脏特异性酶”升高与心肌缺血之间存在统计学上的显著相关性。得出的结论是,只有从手术开始就进行重复测定,才能评估血清酶水平。