Miyazawa K, Honna T, Haneda T, Shirato K, Nakajima T, Arai T
Tohoku J Exp Med. 1978 Dec;126(4):363-9. doi: 10.1620/tjem.126.363.
By means of cineventriculography, contraction pattern of the ventricular septum was studied during electrical stimulation of the right atrium (RA), outflow tract (RVO) and apex (RVA) of the right ventricle and apex (LVA) and lateral wall (LVL) of the left ventricle. RA pacing produced a monophasic shortening of the septal hemiaxes after initial lengthening for about 40 msec from R wave of ECG. In contrast, ventricular stimulation near the septum (i.e. RVO, RVA and LVA) resulted in a biphasic and decreased contraction of the septal wall, in which an early preejection shortening was followed by a brief lengthening and second shortening. LVL pacing showed a monophasic and increased contraction of the septal wall. The biphasic motion of the septal wall was likely to be related to the abnormal mechanical contraction caused by the abnormal conduction sequence of ventricular depolarization. On the other hand, the lateral wall demonstrated a biphasic and decreased contraction during LVL pacing, and a monophasic and increased contraction during RVO, RVA and LVA pacing. Thus, the biphasic and diminished contraction at the site of electrical stimulation was compensated by the monophasic and forceful contraction of the contralateral wall. It is considered that the ventricular septum plays an important functional role in regulation of cardiac performance.
通过电影心室造影术，研究了右心房（RA）、右心室流出道（RVO）和心尖（RVA）以及左心室心尖（LVA）和侧壁（LVL）电刺激期间室间隔的收缩模式。右心房起搏在心电图R波初始延长约40毫秒后，室间隔半轴出现单相缩短。相比之下，在室间隔附近（即RVO、RVA和LVA）进行心室刺激会导致室间隔壁双相且收缩减弱，其中早期射血前期缩短之后是短暂延长和第二次缩短。左心室侧壁起搏显示室间隔壁单相且收缩增强。室间隔壁的双相运动可能与心室去极化异常传导序列引起的异常机械收缩有关。另一方面，左心室侧壁起搏时侧壁显示双相且收缩减弱，而在RVO、RVA和LVA起搏时显示单相且收缩增强。因此，电刺激部位的双相且减弱的收缩由对侧壁的单相且有力的收缩所补偿。据认为，室间隔在心脏功能调节中起重要作用。
