Gottlob R, Hugeneck J
Wien Med Wochenschr. 1982 Sep 30;132(18):415-21.
In dogs the concentrations of agents infused continuously into arteries were assessed in the local and in the systemic circulation. An equation for the gradient between the local and the systemic circulation indicates that in the steady state the gradient is directly proportional to the total clearance of the infused drug and inversely proportional to the blood flow in the infused artery. Within certain limits the gradient is independent of the infused quantity of the drug. By local infusions of antibiotics, such as cefazolin a considerably higher local concentration can be achieved if the local blood flow is impaired, e.g. by arterial disease. By local infusions of streptokinase an increased local fibrinolysis was observed only when the arterial circulation was considerably reduced. Local intraarterial continuously infusions of pharmacologic agents are especially recommended for patients with arterial disease.
在犬类动物中，对持续注入动脉的药物在局部和体循环中的浓度进行了评估。局部与体循环之间梯度的一个方程式表明，在稳态下，该梯度与注入药物的总清除率成正比，与注入动脉中的血流成反比。在一定限度内，该梯度与药物注入量无关。通过局部注入抗生素，如头孢唑林，如果局部血流受损，例如由于动脉疾病，可实现相当高的局部浓度。通过局部注入链激酶，仅当动脉循环显著减少时才观察到局部纤溶增加。对于患有动脉疾病的患者，特别推荐局部动脉内持续注入药理剂。
