Thieme V, Hofmann H, Heiner H, Berger G, Bochynek G
Z Exp Chir. 1982 Oct;15(5):310-9.
Chemical and structural surface changes at enosseous bioglass-ceramic-implants (Ap 40) were investigated by means of electron microprobe after an implantation period of 4 to 52 weeks. An intimate bonding between regenerated bone and bioglass-ceramic surface was evident at points already after 4 weeks. Initial degradation processes at implant surface came to a standstill after 12th week. A calcium and phosphorus rich layer of great importance for implant stability and biocompatibility was formed immediately contacting the bone. This surface layer had a thickness of nearly 25 micrometers -- 30 micrometers at 12 weeks and remains unchanged up to 52 weeks. The registered calcium and phosphorus impulse rate (cps) is equal to that of neighbouring bone. Chemical similarity of implant surface makes bioglass-ceramic Ap 40 a suitable biomaterial for durable bone replacement.
在植入4至52周后，通过电子微探针研究了骨内生物玻璃陶瓷植入物（Ap 40）的化学和结构表面变化。仅在4周后，再生骨与生物玻璃陶瓷表面之间就已明显形成紧密结合。植入物表面的初始降解过程在第12周后停止。紧邻骨骼处立即形成了一层对植入物稳定性和生物相容性极为重要的富含钙和磷的层。该表面层厚度在12周时接近25微米至30微米，并在52周内保持不变。记录的钙和磷脉冲率（cps）与相邻骨骼的相等。植入物表面的化学相似性使生物玻璃陶瓷Ap 40成为用于持久骨替代的合适生物材料。
