Varela V, Houssay A B, Lopardo M I
Acta Physiol Lat Am. 1982;32(1):53-8.
The effects of simulated altitude induced by a decompression chamber upon the blood levels of thyrotropin (TSH), thyroxine (T4) and triiodothyronine (T3), measured by radioimmunoassay, were studied in male Wistar rats. When blood was extracted during the first 15 minutes after the rats were removed from the chamber and analysed, it was found that TSH levels decreased at 380 mmHg during 24 hours and sometimes at 440 mmHg during 24 hours, but this did not happen when the exposure lasted a week. Likewise, serum levels of T4 and T3 decreased at 440 mmHg during 24 hours, but they did not decrease using the same exposure during a week. When the blood was extracted 1 hour after the rats were removed from the chamber and analysed, TSH levels markedly increased at 380 mmHg and at 440 mmHg, during 1 day and during a week. Serum T4 and T3 levels were found to be normal. These results show that severe hypobaric hypoxia is needed in order to depress serum TSH levels. When the rats are removed from the decompression chamber, however, a rebound effect with marked increase in serum TSH levels can be seen before 1 hour elapses.
在雄性Wistar大鼠中，研究了减压舱模拟海拔对通过放射免疫测定法测得的促甲状腺激素（TSH）、甲状腺素（T4）和三碘甲状腺原氨酸（T3）血液水平的影响。当在大鼠从舱中取出后的前15分钟内采集血液并进行分析时，发现TSH水平在24小时内于380 mmHg时下降，有时在24小时内于440 mmHg时也会下降，但当暴露持续一周时则不会发生这种情况。同样，血清T4和T3水平在24小时内于440 mmHg时下降，但在一周的相同暴露期间它们并未下降。当在大鼠从舱中取出1小时后采集血液并进行分析时，TSH水平在1天和一周内于380 mmHg和440 mmHg时均显著升高。血清T4和T3水平被发现是正常的。这些结果表明，需要严重的低压缺氧才能降低血清TSH水平。然而，当大鼠从减压舱中取出时，在1小时过去之前可以看到血清TSH水平显著升高的反弹效应。
