Can left main or proximal left anterior descending coronary artery disease be assessed by non-invasive means?

One hundred consecutive patients with angina pectoris referred for coronary arteriography were studied prospectively for non-invasive assessment of left main (LMCA) or proximal left anterior descending coronary artery (proximal LAD) disease. Evaluation of echocardiographic interventricular septal motion, history and exercise test response could not identify the patients with these specific lesions. It is concluded that LMCA and proximal LAD disease still remain largely unpredictable by non-invasive means.