Onderka D K, Bhatnagar R
Avian Dis. 1982 Oct-Dec;26(4):835-41.
Round heart disease and ascites were induced in 8-day-old turkey poults by administering 0.75% sodium chloride in distilled water. Clinical signs included increased water consumption, loose feces, depression, and increased respiratory rate. Mortality was noticed after 3 days on the saline solution. Light microscopic and electron microscopic studies were made on the right and left free cardiac ventricular walls. Massive glycogen accumulations were demonstrated by periodic acid-Schiff staining and malt diastase digestion. Electron microscopic studies further showed the presence of extensive intrafibrillar glycogen, myofibrillar disarray, lysis of myofilaments, Z-band streaming, and disruption of intercalated discs. These changes are consistent with congestive heart failure and are similar to furazolidone-induced cardiomyopathy. A mechanism is suggested whereby sodium ions may cause hypertension and also act directly to influence the electrical and contractile activity of the heart muscle.
通过给8日龄火鸡雏鸡饮用蒸馏水中0.75%的氯化钠溶液，诱发其出现圆形心脏病和腹水。临床症状包括饮水量增加、粪便变稀、精神沉郁和呼吸频率加快。饮用盐溶液3天后出现死亡。对左右心室游离壁进行了光镜和电镜研究。过碘酸-希夫染色和麦芽淀粉酶消化显示大量糖原积累。电镜研究进一步显示存在广泛的肌原纤维内糖原、肌原纤维排列紊乱、肌丝溶解、Z带流以及闰盘破坏。这些变化与充血性心力衰竭一致，且与呋喃唑酮诱导的心肌病相似。提出了一种机制，即钠离子可能导致高血压，并直接影响心肌的电活动和收缩活动。
