钠离子梯度依赖性刺激对氨基马尿酸盐的肾脏转运
Na+-gradient-dependent stimulation of renal transport of rho-aminohippurate.
作者信息
Sheikh M I, Møller J V
出版信息
Biochem J. 1982 Oct 15;208(1):243-6. doi: 10.1042/bj2080243.
Transport of rho-aminohippurate was studied by the use of a preparation of rabbit kidney basolateral-membrane vesicles and in rat kidney-cortex slices under anaerobic conditions. With both preparations clear evidence of Na+-gradient stimulation of rho-aminohippurate transport ('overshoot') was obtained. These results thus indicate that a significant aspect of active rho-aminohippurate transport is by co-transport with Na+, and they appear to resolve previous disagreements concerning the role of Na+. Vesicle studies with a potential-sensitive dye suggested that rho-aminohippurate may be transported electroneutrally, i.e. in a 1:1 complex with Na+.
利用兔肾基底外侧膜囊泡制剂以及在厌氧条件下的大鼠肾皮质切片研究了对氨基马尿酸的转运。使用这两种制剂均获得了明确的证据，表明对氨基马尿酸转运受到Na⁺梯度刺激（“超射”）。因此，这些结果表明，对氨基马尿酸主动转运的一个重要方面是与Na⁺协同转运，并且它们似乎解决了先前关于Na⁺作用的分歧。用一种电位敏感染料进行的囊泡研究表明，对氨基马尿酸可能以电中性方式转运，即与Na⁺形成1:1复合物进行转运。
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