干细胞调控争议的一个解决方案。
A solution to the controversy on stem cell regulation.
作者信息
Wichmann H E, Loeffler M
出版信息
Blood Cells. 1982;8(2):461-5.
Supplementary to the discussion in Blood Cells 7 (1981) pp. 417-443 concerning regulatory mechanisms of stem cell proliferation and differentiation, the consequences of the two proposed hypotheses of Blackett and Botnick and Lord have been calculated. It can be shown that their equations are equivalent and can be transformed into each other. However, their verbally described regulatory mechanisms are different and turn out to be more important than the equations. The assumptions of Blackett and Botnick lead to an unstable behaviour of the stem cell system with cyclic cell numbers while the hypothesis of Lord leads to stable recovery curves.
作为对《血细胞》7（1981年）第417 - 443页中关于干细胞增殖和分化调控机制讨论的补充，已计算出布莱克特、博特尼克以及洛德提出的两个假设的结果。可以证明，他们的方程是等价的，并且可以相互转换。然而，他们用文字描述的调控机制有所不同，而且事实证明比方程更为重要。布莱克特和博特尼克的假设导致干细胞系统出现细胞数量周期性波动的不稳定行为，而洛德的假设则导致稳定的恢复曲线。
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