• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Effect of alpha-monofluoromethyl histidine, an irreversible inhibitor of histidine decarboxylase, on gestation in mice.

作者信息

Bartholeyns J, Bouclier M

出版信息

Contraception. 1982 Nov;26(5):535-42. doi: 10.1016/0010-7824(82)90152-4.

DOI:10.1016/0010-7824(82)90152-4
PMID:7160183
Abstract

Chronic administration of alpha-monofluoromethyl histidine, a specific inhibitor of histidine decarboxylase, to pregnant mice blocked histidine decarboxylase activity and markedly depleted histamine levels in 18-day-old foetuses and in newborn mice. Such treatment had no effect on implantation or embryonic development or parturition suggesting that de novo synthesis of histamine is not a significant factor in these processes in the mouse.

摘要

相似文献

1
Effect of alpha-monofluoromethyl histidine, an irreversible inhibitor of histidine decarboxylase, on gestation in mice.
Contraception. 1982 Nov;26(5):535-42. doi: 10.1016/0010-7824(82)90152-4.
2
Effect of alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase, on histamine levels in mouse tissues.组氨酸脱羧酶自杀性抑制剂α-氟甲基组氨酸对小鼠组织中组胺水平的影响。
Biochem Pharmacol. 1982 Jul 15;31(14):2367-70. doi: 10.1016/0006-2952(82)90531-7.
3
Effect of prolonged inhibition of histidine decarboxylase on tissue histamine concentrations.
Experientia. 1983 Nov 15;39(11):1303-5. doi: 10.1007/BF01990382.
4
Role of histamine in implantation: inhibition of histidine decarboxylase induces delayed implantation in the rabbit.
Biol Reprod. 1981 May;24(4):867-9. doi: 10.1095/biolreprod24.4.867.
5
alpha-Fluoromethyl histidine. Inhibition of histidine decarboxylase in pylorus ligated rat.α-氟甲基组氨酸。对幽门结扎大鼠体内组氨酸脱羧酶的抑制作用。
Biochem Pharmacol. 1983 May 15;32(10):1553-6. doi: 10.1016/0006-2952(83)90326-x.
6
Effects of alpha-fluoromethylhistidine on increase in histidine decarboxylase activity of maternal mouse kidney observed during late pregnancy and evidence for its non-mast cell origin by using estrogen and W/WV mice.α-氟甲基组氨酸对妊娠后期母鼠肾脏中组氨酸脱羧酶活性增加的影响以及通过使用雌激素和W/WV小鼠证明其非肥大细胞起源的证据
Jpn J Pharmacol. 1985 Oct;39(2):145-51. doi: 10.1254/jjp.39.145.
7
Effects of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase, on development of brain histamine and catecholamine systems in the neonatal rat.组氨酸脱羧酶不可逆抑制剂α-氟甲基组氨酸（FMH）对新生大鼠脑内组胺和儿茶酚胺系统发育的影响。
Life Sci. 1983 Jun 20;32(25):2897-903. doi: 10.1016/0024-3205(83)90326-0.
8
Involvement of histamine in growth of mouse and rat tumors: antitumoral properties of monofluoromethylhistidine, an enzyme-activated irreversible inhibitor of histidine decarboxylase.组胺在小鼠和大鼠肿瘤生长中的作用：单氟甲基组氨酸的抗肿瘤特性，一种组氨酸脱羧酶的酶激活不可逆抑制剂。
Cancer Res. 1984 Feb;44(2):639-45.
9
Selective irreversible inhibition of mammalian histidine decarboxylase by alpha-chloromethyl histidine [proceedings].α-氯甲基组氨酸对哺乳动物组氨酸脱羧酶的选择性不可逆抑制作用[会议论文集]
Agents Actions. 1979 Apr;9(1):38-9. doi: 10.1007/BF02024100.
10
Effect on mast cell histamine of inhibiting histamine formation in vivo with alpha-fluoromethylhistidine.α-氟甲基组氨酸在体内抑制组胺形成对肥大细胞组胺的影响。
Biochem Pharmacol. 1985 Apr 15;34(8):1205-9. doi: 10.1016/0006-2952(85)90496-4.

引用本文的文献

1
Long-term depletion of histamine in guinea-pigs by administration of alpha-fluoromethylhistidine, a specific inhibitor of histidine decarboxylase; effect on the sensitivity of histamine receptors.通过给予组氨酸脱羧酶的特异性抑制剂α-氟甲基组氨酸对豚鼠进行组胺的长期耗竭；对组胺受体敏感性的影响。
Agents Actions. 1988 Jun;24(1-2):56-64. doi: 10.1007/BF01968080.