Constantopoulos A, Davakis M, Malamitsi-Pouchner A, Matsaniotis N
Cytobios. 1982;35(138):103-11.
In 20 jaundiced newborn children with mean bilirubin levels of 19.56 mg/100 ml, a single injection of glucagon was given subcutaneously, in a dosage of 80-300 micrograms/kg of body weight. The bilirubin decreased to 17.05 mg/100 ml within 3 h, and this difference was statistically highly significant (p less than or equal to 0.001). In 14 jaundiced newborn patients with mean bilirubin levels of 16.1 mg/100 ml, normal saline instead of glucagon, was injected subcutaneously (controls). The bilirubin value measured 2-3 h later remained almost the same (16.2 mg/100 ml). In 12 jaundiced newborns with mean bilirubin levels of 17.26 mg/100 ml, a single injection of glucagon was given intravenously, in a dosage of 60-100 micrograms/kg of body weight. The bilirubin decreased to 15.30 mg/100 ml within 2-3 h, and this difference was statistically highly significant (p less than or equal to 0.001). Finally, 10 jaundiced newborn children were injected systematically at 8 am and 8 pm with 300 micrograms/kg of zinc-protamine-glucagon continuously for 5 days. All these patients maintained constant bilirubin levels, and none were sent for phototherapy. In all the patients blood glucose levels were increased between 90 and 130 mg/100 ml, 30 min after glucagon injection.
对20名平均胆红素水平为19.56mg/100ml的黄疸新生儿，皮下注射一次胰高血糖素，剂量为80 - 300微克/千克体重。胆红素在3小时内降至17.05mg/100ml，这一差异具有高度统计学意义（p≤0.001）。对14名平均胆红素水平为16.1mg/100ml的黄疸新生儿患者，皮下注射生理盐水而非胰高血糖素（对照组）。2 - 3小时后测得的胆红素值几乎保持不变（16.2mg/100ml）。对12名平均胆红素水平为17.26mg/100ml的黄疸新生儿，静脉注射一次胰高血糖素，剂量为60 - 100微克/千克体重。胆红素在2 - 3小时内降至15.30mg/100ml，这一差异具有高度统计学意义（p≤0.001）。最后，10名黄疸新生儿从上午8点至晚上8点，每天两次系统性注射300微克/千克的锌-鱼精蛋白-胰高血糖素，持续5天。所有这些患者的胆红素水平保持恒定，且无一例接受光疗。在所有患者中，注射胰高血糖素30分钟后，血糖水平升高至90 - 130mg/100ml之间。
