Klein I, Kraus K E, Martines A J, Weber S
Endocr Res Commun. 1982;9(2):145-53. doi: 10.1080/07435808209045760.
The anterior pituitary gland can be involved in an inflammatory reaction mediated by lymphocytes that leads to various degrees of dysfunction. In seven rabbits immunized with homologous pituitary tissue in complete Freund's adjuvant, a focal lymphocytic infiltrate, and increased fibrosis was observed in five. These changes were patchy in distribution and limited to the anterior pituitary. No inflammation was observed in five control animals. When incubated with pituitary extract, partially purified lymphocytes from four of the five animals with altered pituitary histology demonstrated a significant (p less than 0.05) stimulation of 3H-thymidine incorporation. Measures of antipituitary antibodies using indirect immunofluorescence were negative in experimental as well as control animals. The present studies characterize the histologic changes and suggest that cellular immunity plays a role in the pathogenesis of experimentally induced autoimmune pituitary disease.
垂体前叶可能会参与由淋巴细胞介导的炎症反应，这种反应会导致不同程度的功能障碍。在用完全弗氏佐剂中的同源垂体组织免疫的7只兔子中，5只出现了局灶性淋巴细胞浸润和纤维化增加。这些变化分布不均，局限于垂体前叶。5只对照动物未观察到炎症。用垂体提取物孵育时，5只垂体组织改变的动物中有4只的部分纯化淋巴细胞显示出3H-胸腺嘧啶核苷掺入的显著（p小于0.05）刺激。使用间接免疫荧光检测抗垂体抗体的结果在实验动物和对照动物中均为阴性。本研究描述了组织学变化，并表明细胞免疫在实验性诱导的自身免疫性垂体疾病的发病机制中起作用。
