Kundu S K, Misra L K, Luthra M G
FEBS Lett. 1982 Dec 27;150(2):359-64. doi: 10.1016/0014-5793(82)80768-0.
Gangliosides and neutral glycolipids of muscles from normal and dystrophic chickens were studied. Total glycolipid content of the degenerating muscles was higher than the normal muscles. In addition, the myopathic muscles contained a ganglioside which was absent in the unaffected muscles from normal and dystrophic chickens. Based on the thin-layer chromatographic mobility, treatment with neuraminidases from Vibrio cholerae and Arthrobacter ureafaciens, and reactivity of the asialo-derivative towards anti-ganglio-N-triaosylceramide antibody, the dystrophic-specific ganglioside was tentatively identified as GM2. Data obtained from young and old dystrophic chickens suggested a direct relationship of this ganglioside to muscular dystrophy.
对正常鸡和患营养障碍病鸡的肌肉神经节苷脂和中性糖脂进行了研究。退化肌肉的总糖脂含量高于正常肌肉。此外，患肌病的肌肉含有一种神经节苷脂，而正常鸡和患营养障碍病鸡未受影响的肌肉中不存在这种神经节苷脂。根据薄层色谱迁移率、用霍乱弧菌和脲节杆菌神经氨酸酶处理的结果以及脱唾液酸衍生物对抗神经节苷-N-三糖神经酰胺抗体的反应性，暂将营养障碍特异性神经节苷脂鉴定为GM2。从幼年和老年患营养障碍病鸡获得的数据表明，这种神经节苷脂与肌肉营养不良有直接关系。
