Santinelli V, Chiariello M, Stanislao M, Turco P, Clarizia M, Condorelli M
G Ital Cardiol. 1982;12(6):457-9.
Intravenous mexiletine (3 mg/Kg as bolus) was given to 7 patients with sustained ventricular tachycardia. Previous lidocaine administration in standard doses failed to suppress ventricular tachycardia. Mexiletine successfully suppressed the episodes of ventricular tachycardia in 6 of the 7 patients at a dose of 250 mg. Minimal non-cardiac toxicity occurred after mexiletine administration in the majority of patients. Mexiletine appears to be a promising alternative to lidocaine in the management of ventricular arrhythmias.
对7例持续性室性心动过速患者静脉注射美西律（3毫克/千克推注）。先前给予标准剂量的利多卡因未能抑制室性心动过速。7例患者中有6例在给予250毫克美西律后成功抑制了室性心动过速发作。大多数患者在使用美西律后出现的非心脏毒性最小。在室性心律失常的治疗中，美西律似乎是利多卡因的一个有前景的替代药物。
