Poiffait A, Frangne R, David C, Manent P J, Adrian J
Int J Vitam Nutr Res. 1982;52(4):456-62.
Three groups of 15 rats Wistar receive a well-balanced diet with 40 per cent of sucrose (T), lactose (P) or hydrolyzed lactose (PH) in the form of ultrafiltration permeate. After 160 days, no cataract is revealed in the T and P groups. In the PH group, 14 rats reached by cataracts in both eyes: it is slightly developed (PH 2), mildly developed (PH 3) or practically total (PH 4). The inositol disappearance, the high quantity of galactitol, the water and sodium increases are the factors observed before the lens opacification and are responsible for the cataract. Then, during the opacification, soluble proteins, potassium and hydratation of the lens decrease. Galactose 1-P is slowly formed before and during the lens opacification. The lens of the P group (lactose) differ from the control group (T) by the nature and the quantity of hexitols, only.
三组各15只Wistar大鼠接受均衡饮食，饮食中蔗糖（T组）、乳糖（P组）或水解乳糖（PH组，以超滤渗透物形式）占40%。160天后，T组和P组未出现白内障。在PH组中，14只大鼠双眼出现白内障：白内障发展程度为轻度（PH 2）、中度（PH 3）或几乎完全（PH 4）。肌醇消失、半乳糖醇含量高、水分和钠含量增加是在晶状体浑浊之前观察到的因素，也是白内障形成的原因。然后，在浑浊过程中，晶状体的可溶性蛋白质、钾含量和水合作用降低。在晶状体浑浊之前和过程中，半乳糖1-磷酸缓慢形成。P组（乳糖组）的晶状体与对照组（T组）仅在己糖醇的性质和数量上有所不同。
