Muraji T, Hays D M, Siegel S E, Sleight G, Finkelstein J, Feig S A, Powars D
J Pediatr Surg. 1982 Dec;17(6):843-8. doi: 10.1016/s0022-3468(82)80454-5.
Experience with 72 children in which the type of staging laparotomy recommended by the Intergroup Hodgkin's Disease in Childhood Study (IHDCS) was employed (1967-1981) is reviewed. Laparotomy altered the stage in 35% of these patients including advance in stage (I-II to III-IV) in 24 patients, and reduction in stage (III to II) in one patient. In adults, Stage III disease is divided into III1 and III2 on the basis of the presence or absence of lower abdominal node involvement; and prognosis is significantly better in III1. Nine patients from two additional institutions were included in a special study of Stage III disease. This included 22 children in III1 and 11 children in III2. Although the children with Stage B (systemic symptoms) disease were concentrated in III2, none of the measured difference between these two groups were significant. No fatal postsplenectomy sepsis has been noted since the use of pneumococcal vaccine and prophylactic penicillin became standard.
回顾了1967年至1981年间采用儿童霍奇金病国际协作组研究（IHDCS）推荐的分期剖腹术的72例儿童的经验。剖腹术使35%的这些患者分期改变，包括24例患者分期进展（从I-II期到III-IV期），1例患者分期降低（从III期到II期）。在成人中，III期疾病根据下腹部淋巴结受累情况分为III1和III2期；III1期的预后明显更好。来自另外两个机构的9例患者被纳入III期疾病的专项研究。这包括22例III1期儿童和11例III2期儿童。尽管伴有B期（全身症状）疾病的儿童集中在III2期，但这两组之间的任何测量差异均无统计学意义。自从使用肺炎球菌疫苗和预防性青霉素成为标准治疗以来，未发现致命的脾切除术后败血症。
