Simoneaux B J, Szolics I M, Cassidy J E, Marco G J
J Toxicol Clin Toxicol. 1982 Aug;19(6-7):557-70. doi: 10.3109/15563658208990392.
Recently the Environmental Protection Agency has granted permission to obtain tolerances for pesticide residues in rotation crops. Pesticides applied either pre or postemergence to crops are generally rapidly metabolized in soil to polar and bound residues. These soil residues are usually less available than the applied pesticide for plant uptake. It is a time consuming and difficult task to obtain metabolism data on rotation crops characterized by low uptake. Methidathion, an insecticide for plants, will be used as an example of low uptake by subsequently grown rotation crops. Techniques will be presented to generate large quantities of metabolites utilizing short-term laboratory studies. These metabolites can then be easily identified by the appropriate spectral techniques. Synthesis of standard compounds must be done for comparison to metabolites found in rotation crops. A variety of chromatographic systems will be discussed and evaluated for their suitability for this purpose.
最近，美国环境保护局已批准获取轮作作物中农药残留的耐受性。在作物出苗前或出苗后施用的农药通常会在土壤中迅速代谢为极性和结合态残留物。这些土壤残留物通常比施用的农药更难被植物吸收。获取以低吸收为特征的轮作作物的代谢数据是一项耗时且困难的任务。杀扑磷，一种用于植物的杀虫剂，将作为后续生长的轮作作物低吸收的例子。将介绍利用短期实验室研究生成大量代谢物的技术。然后可以通过适当的光谱技术轻松鉴定这些代谢物。必须合成标准化合物以与轮作作物中发现的代谢物进行比较。将讨论和评估各种色谱系统在此目的上的适用性。
