Gas chromatographic determination of drug levels for the evaluation of a combined hemoperfusion-hemodialysis treatment.

Recently, the use of a prolonged and combined procedure of hemoperfusion (HP) and hemodialysis (HD) was considered as a treatment for severely intoxicated patients caused by drug overdose. Working in cooperation with different hospitals, this laboratory has been involved with the toxicological analysis of biological samples taken during such a treatment. This paper describes the use of a combined HP/HD treatment, especially the evaluation of the system, by giving the analytical results obtained by gas chromatography. The methods utilized enable this application for routine toxicological analysis.