Ismail A A, Amin A M
Neoplasma. 1982;29(6):735-40.
Fluorescence study was carried out in Sprague-Dawley rats injected intravenously with the anti-cancer drug adriamycin (ADR) at a dose of 15 mg/kg to determine the site of its localization in liver. Significant fluorescence emission of ADR nuclear-binding appeared in the liver shortly after the drug administration. The occurrence of the nuclear fluorescence in our material was explained by the binding of ADR to DNA. The cytoplasmic drug loading of liver cells might reflect their role in the drug metabolism.
在体重为15mg/kg的斯普拉格-道利大鼠静脉注射抗癌药物阿霉素（ADR）后进行荧光研究，以确定其在肝脏中的定位部位。给药后不久，肝脏中出现了阿霉素核结合的显著荧光发射。我们材料中核荧光的出现是由于阿霉素与DNA的结合所致。肝细胞的细胞质药物负载可能反映了它们在药物代谢中的作用。
