Courtois P, Meriel P, Dumas C
Ann Anesthesiol Fr. 1975 Sep;16(5):341-7.
1 -- Respiratory depression has been studied in the no anaesthetized rabbit by analysis of the blood gases after an injection of Piritramide (R 3365) and dehydrobenzperidol. 2 -- The respiratory depression induced by Piritramide alone is less important after an injection of dehydrobenzperidol; the most interessant cases are: -- mixture dehydrobenzperidol 400 mug/kg. Pirittramide 1000 mug/kg; --dehydrobenzperidol (400 mug/kg) injected 15 minutes before Piritramide (1000 mug/kg). 3 -- The addition of Dehydrobenzperidol does not take the analgesic activity of Piritramide decrease by it increases it.
通过注射匹利卡明(R 3365)和脱氢苯哌利多后对血气进行分析,在未麻醉的兔子身上研究了呼吸抑制情况。
单独注射匹利卡明所诱导的呼吸抑制在注射脱氢苯哌利多后不太明显;最有趣的情况是:——脱氢苯哌利多400微克/千克与匹利卡明1000微克/千克混合;——在注射匹利卡明(1000微克/千克)前15分钟注射脱氢苯哌利多(400微克/千克)。
添加脱氢苯哌利多不会使匹利卡明的镇痛活性降低,反而会增强其镇痛活性。