Sewell R G, Gallus J A, Nanry K P
Pharmacol Biochem Behav. 1982 Dec;17(6):1225-31. doi: 10.1016/0091-3057(82)90125-3.
Various behavioral sequelae have been noted in patients receiving prolonged, high-dose glucocorticoid therapy. The present study assayed several behavioral dimensions of rats receiving daily intramuscular injections of the synthetic glucocorticoid, prednisolone. Specifically, assessments of water intake, nociception, locomotion, and the grasping responses were conducted; measures of gonadal, adrenal, and total body weights were also taken. Twelve daily injections were given to four groups (N = 6/group) of immature male rats with each group receiving a different dose of drugs (0.0, 8.0, 16.0, 32.0 mg/kg). Prednisolone generally suppressed home-cage water intake, and latencies to hind paw-lick in the hot-plate assay. Measures of wheel running and the grasping response were generally enhanced. Absolute gonadal and adrenal weights as well as total body weights were decreased. Relative organ weights suggested that daily prednisolone treatments had produced suppression of the pituitary-adrenal axis. It was concluded that prednisolone is active in these assays and that such measures may be useful in studies of drug interaction with this agent.
接受长期大剂量糖皮质激素治疗的患者出现了各种行为后遗症。本研究检测了每日肌肉注射合成糖皮质激素泼尼松龙的大鼠的几个行为维度。具体而言，对水摄入量、痛觉感受、运动能力和抓握反应进行了评估；还测量了性腺、肾上腺和总体重。对四组（每组N = 6）未成熟雄性大鼠进行了12次每日注射，每组接受不同剂量的药物（0.0、8.0、16.0、32.0 mg/kg）。泼尼松龙通常会抑制笼内水摄入量以及热板试验中后爪舔舐的潜伏期。转轮运动和抓握反应的测量结果通常会增强。性腺和肾上腺的绝对重量以及总体重均下降。相对器官重量表明，每日泼尼松龙治疗导致了垂体-肾上腺轴的抑制。得出的结论是，泼尼松龙在这些试验中具有活性，并且这些测量方法可能有助于研究与该药物的相互作用。
