Merker P C, Yeung D, Doughty D, Nacht S
Res Commun Chem Pathol Pharmacol. 1982 Dec;38(3):367-88.
Pharmacokinetic data on resorcinol were obtained from studies in the rat. The drug, administered subcutaneously in an aqueous solution, rapidly cleared plasma vir urine and did not accumulate in tissues. In the urine, the major metabolite of resorcinol was the glucuronide. Repeated dosing for 30 days with maximum tolerated daily doses of 100 mg/kg did not alter pharmacokinetic parameters, nor did it cause overt toxic signs or adverse reactions. The animals' body weight, blood values, levels of serum T3 and T4' and the gross and microscopic appearance of the thyroid gland and spinal cord remained within normal limits throughout the study.
间苯二酚的药代动力学数据来自大鼠研究。该药物以水溶液形式皮下给药后，能迅速从血浆和尿液中清除，且不会在组织中蓄积。尿液中，间苯二酚的主要代谢产物是葡萄糖醛酸苷。以最大耐受日剂量100mg/kg重复给药30天，并未改变药代动力学参数，也未引起明显的毒性体征或不良反应。在整个研究过程中，动物的体重、血液指标、血清T3和T4水平以及甲状腺和脊髓的大体及显微镜下外观均保持在正常范围内。
